DOI: 10.1039/d3cc01945d ISSN: 1359-7345

5-Dihydroxyboryluridine enhances cytosolic penetration of antisense oligonucleotides

Sam Kavoosi, Kirsten Deprey, Joshua A. Kritzer, Kabirul Islam
  • Materials Chemistry
  • Metals and Alloys
  • Surfaces, Coatings and Films
  • General Chemistry
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Catalysis

Boronic acid functionalized synthetic antisense oligonucleotides demonstrate enhanced cellular uptake and biological activity, constituting a novel approach for delivery of therapeutic oligonucleotides.

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