DOI: 10.1039/d3cc01945d ISSN: 1359-7345
5-Dihydroxyboryluridine enhances cytosolic penetration of antisense oligonucleotides
Sam Kavoosi, Kirsten Deprey, Joshua A. Kritzer, Kabirul Islam- Materials Chemistry
- Metals and Alloys
- Surfaces, Coatings and Films
- General Chemistry
- Ceramics and Composites
- Electronic, Optical and Magnetic Materials
- Catalysis
Boronic acid functionalized synthetic antisense oligonucleotides demonstrate enhanced cellular uptake and biological activity, constituting a novel approach for delivery of therapeutic oligonucleotides.