Balasubrahmanya K. Sathyanarayana, Kiran B. Manjappa, Ding-Yah Yang

4-Chloro-3-nitrocoumarin as a precursor for synthesis of 2-arylchromeno[3,4-b]pyrrol-4(3H)-ones: a case of nitro group directed reductive coupling

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

An unprecedented, base-mediated, nitro group-directed reductive coupling of 4-chloro-3-nitrocoumarin with α-bromoacetophenone under metal-free conditions is reported. The subsequent reductive intramolecular cyclization leads to versatile pyrrolocoumarins.

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