#197 : The Associations Between Modifiable Risk Factors and Spontaneous Abortion: A Two-Sample Mendelian Randomization Study

Back and Aims: Early identification of modifiable risk factors is essentialfor the prevention of spontaneous abortion (SA). We aimed to systematically explore the relationships between genetically predicted modifiable risk factors and SA.

Method: We obtained genetic variants associated with the modifiable risk factors at the genome-wide significance (p< 5× [Formula: see text]) level from genome-wide association studies (GWAS). Two-sample Mendelian Randomization (MR) analysis was used to investigate the relationship between 42 modifiable risk factors and SA.

Results: The studyfound that genetically predicted HLA DR++ monocyte %leukocyte, HLA DR on CD14+ monocyte, HLA DR on monocyte, and type of transport used were associated with an increased risk of SA (all with [OR]>1 and p< 0.05). Conversely, CD14+ CD16- monocyte absolute count, age first had sexual intercourse, never smoked, and education status were found to be negatively associated with SA (all with [OR]<1 and p< 0.05). Additionally, the study observed potential associations between genetically predicted CD25 on switched memory B cell, lymphocyte count, monocyte absolute count, CD8+ natural killer T %T cell, asthma, appendicular lean mass, rheumatoid arthritis, complement C1q tumor necrosis factor-related protein 1 (CTRP1), hand grip strength, waist-to-hip ratio, and usual walking pace with an increased risk of SA. Conversely, lymphocyte count was associated with a suggestive lower risk of SA in the results.

Conclusion: Our analysis revealed that several modifiable risk factors were associated with SA. Specifically, genetically predicted a higher proportion of HLA DR++ monocytes in leukocytes, HLA DR on CD14+ monocyte, HLA DR on monocyte and often using cycle as transportation were associated an increased risk of SA, while evaluated CD14+ CD16- monocyte absolute count, first sexual intercourse at an older age, never smoked, and higher education were with a decreased risk of SA.