DOI: 10.1097/rlu.0000000000005145 ISSN: 1536-0229

18F-Florbetapir PET/CT and 68Ga-FAPI PET/CT in a Case of Light Chain Amyloidosis With Predominant Multiple Tumor-Like Deposits

Yuke Zhang, Xuezhu Wang, Chao Ren, Kaini Shen, Li Huo
  • Radiology, Nuclear Medicine and imaging
  • General Medicine


A 66-year-old man presented with multiple masses in different regions, including the left groin, back subcutaneous area, and lungs. Pathological examination confirmed localized amyloid deposits after 3 surgeries. Serum-free λ light chains were elevated. To evaluate systemic involvement, the patient underwent 18F-Florbetapir PET/CT and 68Ga-FAPI-04 PET/CT. Both scans showed increased uptake in multiple masses and nodules throughout the body. This report presents a rare case of light chain (AL) amyloidosis, primarily characterized by multiple localized tumor-like deposits with high activity on 18F-Florbetapir PET/CT and 68Ga-FAPI-04 PET/CT.

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