147. CHARACTERISTICS AND PREDICTORS OF EARLY POSTOPERATIVE RECURRENCE OF ESOPHAGEAL CANCER
Shinsuke Sato, Erina Nagai, Yusuke Taki, Masato Nishida, Masaya Watanabe, Noriyuki Oba- Gastroenterology
- General Medicine
Abstract
Background
Recurrence after radical esophageal cancer surgery is known to occur in 30–50% of cases, mostly within 2 years after surgery. This study aimed to clarify the characteristics of patients with early recurrence within 6 months after esophageal cancer surgery and the risk factors for early recurrence.
Methods
A total of 350 patients who underwent esophagectomy between January 2011 and August 2021 were included in this study. Patient background factors were compared among three groups: the early recurrence group with recurrence within 6 months after surgery, the late recurrence group with recurrence after 6 months after surgery, and the recurrence-free group. Multivariate logistic regression was used to analyze the association between various predictors and early postoperative recurrence.
Results
Postoperative recurrence occurred in 141 patients (40.1%). Recurrence within 6 months after surgery occurred in 65 patients, and recurrence after 6 months in 76 patients. The proportion of advanced clinical stage increased in patients with early postoperative recurrence. Significant differences between the three groups were found for CRP, SCC, Neutrophil, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio. Prognostic nutrition index、advanced lung cancer inflammation (BMI × Alb/NLR) were significantly less in patients with early postoperative recurrence. Multivariate analysis showed that clinical stage, pathological lymph node metastasis, and NLR were independent prognostic factors for early postoperative recurrence.
Conclusions
Preoperative NLR may be a valuable early postoperative recurrence factor for patients with esophageal cancer undergoing esophagectomy.