DOI: 10.1039/d6ra05893k ISSN: 2046-2069
1,2,3-Triazolyl indole-piperazine hybrids as potential anti-tubercular agents: design, synthesis, in vitro , and in silico evaluation
Rajkumar Reddyrajula, Umadevi Etikyala, Mohammed Muzaffar-Ur-Rehman, Sampat Parayya Vibhutimath, Udayakumar Dalimba, Shreeganesh Subraya Hegde, Chandra Sekhar Kondapalli Venkata Gowri, Vijjulatha MangaA series of two sets of 1,2,3-triazolyl indole-piperazine hybrids (R1–R17) were synthesized and tested against M.tb H37Rv, with R11 exhibiting significant potency with an MIC of 1.56 µg mL −1 , equipotent to the first-line drug isoniazid.