DOI: 10.1093/cid/ciag393 ISSN: 1058-4838
10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the “Ceiling Efficacy Effect” of Modern Antifungals?
Ariel D Szvalb, Sebastian Wurster, Takahiro Matsuo, Teny M John, Adam G Stewart, Sung-Yeon Cho, Ying Jiang, Dimitrios P KontoyiannisAbstract
Given competing death causalities among hematological malignancy patients with invasive aspergillosis (IA), we assessed IA-attributable, contributable, and all-cause mortalities in patients with culture-confirmed IA. Although attributable mortality decreased, contributable and all-cause mortalities remained high. Our data suggest that improving survival would require host augmentation, in addition to improved antifungals.