DOI: 10.3390/m2216 ISSN: 1422-8599
(±)-2-Chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylacetamide
Diyana Dimitrova, Stanimir Manolov, Iliyan Ivanov, Dimitar Bojilov, Paraskev NedialkovHerein, we report the rapid mechanochemical synthesis of a novel hybrid amide, (±)-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylacetamide. The target compound was obtained via direct acylation of 1,4-benzodioxan-6-amine with (±)-2-chloro-2-phenylacetyl chloride under ball-milling conditions in only 1 min. Its structure was confirmed by 1H and 13C NMR, IR spectroscopy, and HRMS.