DOI: 10.66106/swcabp.20260308 ISSN: 3105-6652

异维 A 酸联合他克莫司软膏治疗脂溢性皮炎的有效性及安全性探讨

王凤娟 Fengjuan Wang
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Abstract：Objective：To evaluate the efficacy，safety，treatment satisfaction and short-term recurrence rate of oral isotretinoin combined with topical tacrolimus ointment in the treatment of seborrheic dermatitis（SD）. Methods：A total of 120 patients with SD diagnosed at the dermatology outpatient clinic of our hospital from January to December 2025 were enrolled and randomly divided into combination group（n=60）and control group（n=60）. The combination group received oral isotretinoin（0.3 mg/（kg·d））plus topical 0.1% tacrolimus ointment，while the control group received 0.1% tacrolimus ointment alone；the treatment duration was 8 weeks for both groups. Clinical efficacy，adverse events，treatment satisfaction and recurrence rate within 4 weeks after treatment were compared between the two groups. Results：The total effective rate of the combination group was 100.0%（60/60），higher than 91.7%（55/60）of the control group（P<0.05）. The incidence of adverse events in the combination group was 18.3%（11/60），lower than 41.7%（25/60）in the control group（P<0.05）. The satisfaction rate of the combination group was 96.7%（58/60），higher than 81.7%（49/60）of the control group（P<0.05）. The recurrence rate within 4 weeks of follow-up was 5.0%（3/60）in the combination group，lower than 16.7%（10/60）in the control group（P<0.05）. Conclusion：Oral isotretinoin combined with topical tacrolimus ointment can significantlyimprove the clinical efficacy and treatment satisfaction，and reduce the short-term recurrence rate of SD，with a low incidence of adverse events；it is safe and worthy of clinical promotion.

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