K. P. Fung, S. P. Lau

γ‐Glutamyl Transpeptidase Activity and Its Serial Measurement in Differentiation Between Extrahepatic Biliary Atresia and Neonatal Hepatitis

  • Gastroenterology
  • Pediatrics, Perinatology and Child Health

The liver functions of 17 babies with extrahepatic biliary atresia (EHBA) and 19 babies with neonatal hepatitis (NNH) were analyzed. The serum γ‐glutamyl transpeptidase (GGTP) level and its rate of rise were significantly higher in the EHBA group. Both cross‐sectional and longitudinal studies showed a positive cor‐relation between the GGTP activity and the duration of the disease. The diagnostic accuracy is 79% for EHBA and 95% for NNH. It is suggested that GGTP and its rate of rise are the most important biochemical parameters in the differential diagnosis of these two diseases.

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