DOI: 10.3390/molecules29245927 ISSN: 1420-3049
β,β-Difluoro Peroxides as Fluorinated C2-Building Blocks for the Construction of Functionalized Indolizines
Yangyang Ma, Hua Zhang, Xiaoxiao Du, Shurui Fang, Kexin Yin, Gangfeng Du, Zhengshan Tian, Zhonghao ZhouAn effective method for the construction of functionalized indolizines has been developed in which β,β-difluoro peroxides act as novel C2-building blocks to implement [3+2] annulation with pyridinium ylides under base-mediated conditions. With this protocol, a broad range of multisubstituted indolizines were prepared in moderate to good yields under mild conditions, and many useful functional groups were tolerated.