Vital microscopy of the microcirculation the bed of the mesentery of the small intestine in the dynamics of acute poisoning by sodium nitrite

Objective. Study of the state of hemo and lympho-microcirculatory bloodstream of the mesentery of the small intestine of a rat in the dynamics of acute oral poisoning by sodium nitrite. Materials and methods. The experiments were performed on 50 white rats weighing 180200 g, divided into 2 groups: I intact (control) - 20 and II - model of acute sodium nitrite poisoning (experiment) - 30.The poisoning was reproduced by oral administration to anesthetized animals through a probe into the stomach of sodium nitrite at a dose of 50mg / kg. Results. There was biomicroscopic noted a general slowing of the blood flow in 30 minutes after intoxication. On the back of vasodilatation in arterioles and precapillaries the blood flow slowed down and became continuous homogeneous or granular.Morphometry showed the expansion of the diameter of all links of the lympho-microcirculatory bloodstream of mesentery of the small intestine, compared with intact values. There wasdeterminedan increase in the diameter of arterioles by 22 (compared with the control), precapillaries - by 18.8, a decrease in the number of perfusable capillaries in90 minutes after intoxication. The average diameter of the capillaries increases by 31.4 (compared with the control).Postcapillaries and venules were distinguished by plethora, great tortuosity and slower blood flow.The increase in the diameter of postcapillaries and venules compared with the control was 20.4 and 23, respectively.The diameter of the lymphatic vessels increased by 30 (compared with the control). There was revealed an aggravation of signs of impaired hemomicrocirculation after 180 minutes, biomicroscopy. The number of drugs with deformed contours increased. The number of lymphangion contractions decreased to 1-2 in 1 minute.Their diameter compared with the intact increased by 40 (P 0.05). Conclusion. In 30 minutes after acute (LD50) oral poisoning with sodium nitrite the changes in the lympho-microcirculatory bloodstream of the mesentery of the small intestine are manifested in an intensive increase by 90 and 180 minutes of intoxication: vasodilation of the resistive link with a decrease in the rhythm of their vasomotion, venular hypertension, increased arteriole venous bypass surgery, vascular tortuosity, total venous hypertension, increased arteriole venous bypass surgery, vascular tortuosity, total venous hypertension, increased arteriole venous bypass surgery, vascular sinuosity, general venous hypertension, increased arteriole venous bypass surgery, vascular sinuosity, total venous hyperpression. In the lymphatic vessels a weakening of the motility rhythm of the lymphangion is progressing, with the appearance of the formed elements of blood in the lumen.