DOI: 10.1002/cai2.90 ISSN:
The expression and function of long noncoding RNAs in hepatocellular carcinoma
Jingli Du, Yue Su, Jianzhi Gao, Yanhong Tai- Pharmacology (medical)
- Cancer Research
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Drug Discovery
- Oncology
Abstract
With the deepening of the genome project study, attention on noncoding RNAs is increasing. Long noncoding RNAs (lncRNAs) have become a new research hotspot. A growing number of studies have revealed that lncRNAs are involved in tumorigenesis and tumor suppressor pathways. Aberrant expressions of lncRNAs have been found in a variety of human tumors including hepatocellular carcinoma (HCC). In this review, we provide a brief introduction to lncRNA and highlight recent research on the functions and clinical significance of lncRNAs in HCC.