THE EFFECTS OF ESOMEPRAZOLE ON ALCOHOL INDUCED STRESS ULCER LESIONS IN RATS

<p>Stress ulcer presents acute lesion of gastric mucosa, which resulted from influence of different stressors: trauma,<br />shock, burns, drugs administration, various irritants etc. Since pathogenesis of stress ulcer is not completely clarified, the<br />most adequate therapy for the patients which suffer from it, is not defined yet. Esomeprazole is a S-isomer of omeprazole<br />and is the first inhibitor of proton pump synthesized as an isomer. Our aim was to test effects of esomeprazole, given during<br />pretreatment and posttreatment period, on progress of alcohol induced stress ulcer lesions. We had experiments on sexually<br />mature Wistar rats weight 200-250 g. Alcohol stress was induced by intragastric administration of 1 mL 96% alcohol.<br />Alcohol stress produced massive submucosal lesions in glandular part of stomach. Macroscopic lesions were verified<br />histologicaly. Intragastric pretreatment administration of esomeprazole (20 mg/kg BW) significantly (p<0,001) reduced gastric lesions. Intragastric post-treatment administration of esomeprazole (20 mg/kg BW) did not reduce gastric lesions. Esomeprazole (20 mg/kg BW) administrated in pretreatment period of alcohol induced stress significantly decreased dimensions of stress ulcer lesions in rats, while the same dose administrated in posttreatment period did not cause that effect.</p>