The Association of CAG Polymorphism in the Androgen Receptor Gene with Nodulocystic Acne in Egyptians
Mo'mena Nagy Essa, Nader Fouad Ragab, Nehal Mohamed Zuel Fakkar, Abeer Alsayed Ali Shehab- General Medicine
Abstract
Acne vulgaris is a pilosebaceous inflammatory condition with several etiologies. Hormones have a crucial role in the development of acne. Hypersensitivity of the androgen receptor gene (ARG), which is the sole receptor for androgens, was reported to share in the pathogenesis of acne. At the 5'end of exon 1 of chromosome X, ARG has a polymorphism of CAG triple loop that codes for the polyglutamine pathway.
Aim of the Study
The aim of this study was to investigate CAG repeat polymorphism in the ARG in Egyptian nodulocystic acne patients to clarify its relevance to the pathogenesis of nodulocystic acne.
Patients and Methods
Twenty-five patients with severe and very severe nodulocystic acne and 25 apparently healthy control subjects were included in the current study. Full general, dermatological assessment and acne severity determination were performed through GAGS score before genetic analysis to determine CAG repeat number in included participants.
Results
Genetic analysis of CAG repeats number revealed that male and female acne patients had significantly lower number of CAG repeats compared to control subjects. Moreover, after gender correction, acne patients still had significantly lower number of CAG repeats compared to control subjects.
Conclusion
the current study revealed that acne patients had significantly lower number of CAG repeats compared to controls.