DOI: 10.1055/a-2235-5080 ISSN: 0039-7881
Short Synthesis of Dopamine Agonist Rotigotine
Chandra Shekhar, Santanu Karmakar, Prathama S Mainkar, Srivari Chandrashekar- Organic Chemistry
- Catalysis
A practical and short synthesis of FDA approved drug, Rotigotine is achieved in two steps from 5-methoxy-2-tetralone which in turn was synthesised using [4+2] cycloaddition of methoxy aryne and benzyloxy butadiene or from 4-methoxy indanone via ring expansion using trimethylsilyl diazomethane.