Recent Progress in Steroid C(sp³)−H Functionalization

Abstract

Selective C−H functionalization methods could provide a valuable tool for synthesizing different steroid derivatives, which is essential not only in contexts of developing novel synthetic methodology but also as a direct way for gathering the analogues needed for studying the structure‐activity relationships and obtaining biologically active compounds. The review discusses recent examples of steroid C−H functionalization to various C−X derivatives (C−O, C−C, C−N, C−S, and C−halogen) using available methods emphasizing their scope and limitations.