DOI: 10.1161/jaha.124.034242 ISSN: 2047-9980

Perfusion‐Based Relative Cerebral Blood Volume Is Associated With Functional Dependence in Large‐Vessel Occlusion Ischemic Stroke

Dhairya A. Lakhani, Aneri B. Balar, Manisha Koneru, Sijin Wen, Burak Berksu Ozkara, Justin Caplan, Adam A. Dmytriw, Richard Wang, Hanzhang Lu, Meisam Hoseinyazdi, Mehreen Nabi, Ishan Mazumdar, Andrew Cho, Kevin Chen, Sadra Sepehri, Nathan Hyson, Risheng Xu, Victor Urrutia, Licia P. Luna, Argye Hillis, Jeremy J. Heit, Greg W. Albers, Ansaar T. Rai, Tobias Faizy, Max Wintermark, Kambiz Nael, Vivek S. Yedavalli
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Background

Pretreatment computed tomography perfusion parameter relative cerebral blood volume (rCBV) lesion volume has been shown to predict 90‐day modified Rankin Scale score in small‐core strokes with Alberta Stroke Program Early Computed Tomography Score ≥5, including those with medium‐vessel occlusions (mid and distal M2 segment occlusions). Hence, in this study we aim to assess the performance of different rCBV lesion volume thresholds (rCBV <42%, rCBV <38%, and rCBV <34%) with 90‐day modified Rankin Scale score including patients with large core (Alberta Stroke Program Early Computed Tomography Score <5) and strictly including only patients with anterior circulation large‐vessel occlusion.

Methods and Results

In this retrospective evaluation of our prospectively collected database, inclusion criteria were (1) Computed tomographic angiography confirmed anterior circulation large‐vessel occlusion from September 1, 2017, to October 1, 2023; and (2) diagnostic computed tomography perfusion. Student t test, Mann–Whitney U test, and χ 2 test were used in the univariate data analysis. Spearman's rank correlation analysis was used to assess correlations. Outcome measure was dichotomized into good functional outcome (90‐day modified Rankin Scale score, 0–2) and poor functional outcome (90‐day modified Rankin Scale score, 3–6) for logistic regression and receiver operating characteristic analysis. P ≤0.05 was considered significant. In total, 229 patients met our inclusion criteria. The majority of the patients (n=161) in our cohort had M1 occlusion. All the rCBV thresholds were significantly higher in patients with poor 90‐day functional outcomes and were independently associated with the outcome. Spearman's rank correlation analysis revealed a slightly stronger correlation of rCBV <42% (ρ=0.27, P <0.001), as compared with rCBV <38% (ρ=0.25, P <0.001) and rCBV <34% (ρ=0.24, P <0.001) with functional outcome. Receiver operating characteristic analysis revealed that rCBV <42% (area under the curve, 0.67 [95% CI, 0.60–0.74]; P <0.001) performed marginally better than rCBV <38% (area under the curve, 0.66 [95% CI, 0.59–0.73]; P <0.001), and rCBV <34% (area under the curve, 0.65 [95% CI, 0.58–0.72]; P <0.001).

Conclusions

All the rCBV thresholds were independently associated with poor 90‐day functional outcome; however, the rCBV <42% marginally outperformed rCBV <38% and rCBV <34% lesion volumes.

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