Ischemia heart disease is a top non-communicable disease that causes more deaths worldwide and it increases progressively over the years. It becomes a burden to low and middle-income countries. The management and treatment of ischemia heart disease become more challenging due to improper lifestyle, adverse effects of currently available drugs, limited access to various diagnostic methods, genetic variations, and lack of knowledge among healthcare professionals. In this comprehensive survey, we summarized the different kinds of diagnostic approaches and modes of therapy, current research, molecular and genetic basis, future directions like integrative therapy and precision medicine, and global health initiatives related to IHD to create awareness that will help healthcare professionals to save the life of patients and researchers to develop a new molecule to treat ischemia heart disease.