DOI: 10.1093/bjd/ljad283 ISSN:
Integrative serum proteomics analysis reveals distinct immune and cardiovascular profiles dysregulation in erythrodermic psoriasis
Biao Song, Chao Wu, Weida Liu, Yanang Wang, Xin Ning, Lan Guo, Xiaohan Liu, Yimeng Gao, Hongzhong Jin- Dermatology
In-depth analysis of circulating proteome alterations identified that erythrodermic psoriasis (EP) presented a dysregulated serum proteome with distinct inflammation elevation, immune activation and metabolic disturbance. We found that EP harbored a blended immune milieu with distinct TH17/TH1 skewing and mild TH2 activation. Additionally,Atherosclerosis signaling were substantially increased in EP.