Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats
Samira Behrad, Sina Pourranjbar, Mohammad Pourranjbar, Saeid Abbasi-Maleki, Samira Rostami Mehr, Reza Hossein Gholizadeh Salmani, Nasrollah MoradikorObjective:
To evaluate the effect of
Methods:
Seventy-five rats were divided into five groups: the normal control group and the AD group treated with or without GFP (100, 200, and 400 mg/kg). Behavioral responses in the open field test and elevated plus maze test were assessed. Additionally, the levels of malondialdehyde and ferric-reducing ability of plasma, and the mRNA expressions of
Results:
Treatment with GFP significantly improved AD-induced behavioral changes in the open field test and elevated plus maze test (
Conclusions:
Oral administration of GFP can reduce inflammation and oxidative stress, as well as improve behavioral responses associated with AD, suggesting its potential use in AD treatment. However, additional studies are needed to elucidate its underlying mechanisms and efficacy.