DOI: 10.1128/msystems.00191-16 ISSN:
Deblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns
Amnon Amir, Daniel McDonald, Jose A. Navas-Molina, Evguenia Kopylova, James T. Morton, Zhenjiang Zech Xu, Eric P. Kightley, Luke R. Thompson, Embriette R. Hyde, Antonio Gonzalez, Rob Knight- Computer Science Applications
- Genetics
- Molecular Biology
- Modeling and Simulation
- Ecology, Evolution, Behavior and Systematics
- Biochemistry
- Physiology
- Microbiology
Deblur provides a rapid and sensitive means to assess ecological patterns driven by differentiation of closely related taxa. This algorithm provides a solution to the problem of identifying real ecological differences between taxa whose amplicons differ by a single base pair, is applicable in an automated fashion to large-scale sequencing data sets, and can integrate sequencing runs collected over time.