DOI: 10.1126/science.277.5327.818 ISSN:
Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
James P. Sheridan, Scot A. Marsters, Robert M. Pitti, Austin Gurney, Maya Skubatch, Daryl Baldwin, Lakshmi Ramakrishnan, Christa L. Gray, Kevin Baker, William I. Wood, Audrey D. Goddard, Paul Godowski, Avi Ashkenazi- Multidisciplinary
TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.