COMPARATIVE STUDY OF LIPID PROFILE IN PATIENTS OF TYPE 2 DIABETES MELLITUS WITH AND WITHOUT ASSOCIATED HYPOTHYROIDISM IN A TERTIARY CARE HOSPITAL, BARABANKI

Aim: To study lipid prole in T2DM patients with and without associated hypothyroidism. In this case-control study, a total of 50 T2DM Method: patients with hypothyroidism and an equal number of T2DM patients without hypothyroidism were enrolled as cases and controls respectively. Demographic and anthropometric proles of two groups were noted, blood pressure, blood glucose (fasting, PP), Hb A and lipid levels were 1c assessed. Data was analysed using SPSS 21.0 version. Chi-square and Student t-test were used to compare the data. Results: Mean age of cases and controls was 48.46±9.82 and 53.12±9.92 years respectively (p=0.020). Signicantly higher proportion of cases as compared to controls were females (60% vs 28%) (p=0.001) and homemakers (40% vs 20%) (p=0.001), had previously diagnosed hypertension (20% vs 6%) (p=0.003), diabetic treatment (56% vs 14%), sleep deprivation (14% vs 2%), altered bowel habits (22% vs 0%), higher BMI (29.51 vs 27.34), overweight and obesity (80% vs 52%), higher blood pressure, blood glucose and HbA . Mean triglyceride and VLDL levels were also signicantly higher in cases 1c as compared to that of controls (p<0.05). Prevalence of dyslipidemia was 84% in cases as compared to 64% in controls, thus showing a signicant difference between two groups (p=0.028). The ndings of the study showed that T2DM patients with hy Conclusion: pothyroidism have a high prevalence of metabolic abnormalities. The prevalence of dyslipidemia was signicantly higher in T2DM patients with hypothyroidism as compared to that in T2DM patients without hypothyroidism