DOI: 10.1039/d3cc01963b ISSN:

Charged chiral derivatization for enantioselective imaging of d-,l-2-hydroxyglutaric acid using ion mobility spectrometry/mass spectrometry

Eiji Sugiyama, Yuki Nishiya, Kenji Yamashita, Ryo Hirokawa, Yoshiteru Iinuma, Takashi Nirasawa, Hajime Mizuno, Yoshitaka Hamashima, Kenichiro Todoroki
  • Materials Chemistry
  • Metals and Alloys
  • Surfaces, Coatings and Films
  • General Chemistry
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Catalysis

A newly synthesized charged chiral tag-enabled enantioselective imaging of

d
- and
l
-2-hydroxyglutaric acid, which are independently associated with the regulation of DNA methylation, using MALDI/ion mobility spectrometry/mass spectrometry.

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