Change in adiposity indices after one year of peritoneal dialysis: a single center cohort study
Zhikai Yang, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Cheuk-Chun SzetoAbstract
Background
Weight gain is common after starting peritoneal dialysis (PD). Several adiposity indices have been developed recently as potential indicators of visceral adiposity and lipid accumulation. We aim to investigate the prevalence and prognostic implications of the change in adiposity indices after one of PD.
Methods
We recruited 110 patients treated with PD for 12 months. Adiposity indices, including triglyceride glucose index, lipid accumulation product, visceral adiposity index, and conicity index were measured at baseline and then one year after PD started. The relation between their changes (Δ) and other clinical and biochemical parameters, as well as survival and hospitalization rates were analyzed.
Results
After one year of PD, more than half of the patients had their adiposity indices increased. The change in adipose tissue mass significantly correlated with the concomitant changes in triglyceride glucose index (ΔTyGI) (r = 0.25, p = 0.01), lipid accumulation product (ΔLAP) (r = 0.27, p = 0.007) and visceral adiposity index (ΔVAI) (r = 0.26, p = 0.01). ΔTyGI significantly correlated with the change in insulin resistance as represented by HOMA-IR (r = 0.22, p = 0.02), while ΔLAP and change in conicity index (ΔCI) correlated with the changes in various anthropometric parameters. However, no indices variation was associated with patient survival, technique survival, or hospitalization rate.
Conclusions
Increased adiposity indices were common after one year of PD. The changes in adiposity indices had variable correlation with the change in adipose tissue mass, insulin resistance, and anthropometric parameters. Further studies are required to identify simple metabolic parameters with a prognostic impact, that could be suitable for serial monitoring.