DOI: 10.4103/mjbl.mjbl_925_23 ISSN: 1812-156X

Biofilm Forming Intestinal Escherichia coli as a Risk Factor for Increasing BMI in Type 2 Diabetic Patients

Sahar Salih Hussein, Asal Aziz Tawfeeq
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Abstract

Background:

The term diabetes mellitus (DM) describes a group of chronic diseases and metabolic disorders that accompany hyperglycemia (high blood glucose) which may be the result of an abnormality in secretion or insulin action. Diabetes type 2 is the most common type of diabetes, it usually occurs in adults but is increasingly with overweight. On the other hand, gut bacteria have a key role in the regulation of different metabolic pathways that are important in glucose homeostasis and diabetes type 2 pathogenesis.

Objectives:

This study aimed to analyze the effect certain gut and biofilm formation on the glucose homeostasis and BMI in diabetic females.

Materials and Methods:

This study included the collection of 180 samples from diabetic and non-diabetic participants (20–50 years) during the period from December 2022 to March 2023. BMI was calculated for study participants, and Escherichia coli was microbiologically and biochemically identified.

Results:

The results demonstrated a substantial (P < 0.05) increase of 80% in biofilm formation E. coli in diabetic patients with greater BMI than those without diabetes with lower BMI.

Conclusion:

This study showed a significant relationship between intestinal bacteria (specially E. coli) and diabetes causing increased BMI, leading to probable useful tools for developing strategies to prevent obesity.

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