DOI: 10.1039/d3cp02628k ISSN:
Binding of synthetic nanobodies to the SARS-CoV-2 receptor-binding domain: the importance of salt bridges
Hujun Shen, Hengxiu Yang- Physical and Theoretical Chemistry
- General Physics and Astronomy
The salt bridges between RBD and synthetic nanobodies are crucial for binding synthetic nanobodies to RBD. The binding of nanobodies to RBD or its mutants can be improved by increasing the electrostatic attraction between them (especially the formation of salt bridges).