DOI: 10.1097/ms9.0000000000001204 ISSN:

Association of Vitamin D and Functional Dyspepsia- A case control study

Dhriti Sundar Das, Gautom Kumar Saharia, Manas Kumar Panigrahi, Debananda Sahoo
  • General Medicine
  • Surgery
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Background:

Vitamin D plays a key role in responses of brain gut axis. It has been suggested that functional dyspepsia (FD) may be associated with decreased levels of vitamin D. Hence this study wished to find the association between vitamin D in patients with functional dyspepsia.

Materials and Methods:

This case control study was done at a tertiary care hospital with 150 cases and 150 controls. FD was diagnosed by the ROME IV criteria. Demographic profile and serum vitamin D levels including perceived stress score (PSS) and salivary amylase were determined for both cases and controls.

Results:

Majority of the FD cases were males (57.3%). Post prandial distress syndrome represented the major type of FD cases (69.3%). A higher mean BMI was found among the control group (23.2 vs. 21.2, P<0.05) and higher percentage of obese individuals in the control group (42.7% vs 29.3%, P= 0.05). Majority of the cases are from rural background (89.3% vs 74%, P<0.001). Comparison of PSS showed that cases had significantly higher grades of PSS than control (P<0.001). However, no significant association was found in the levels of salivary amylase between the groups (P=0.728). Hypovitaminosis D (<30 ng/ml) was found significantly more among cases than controls (73.3% vs 60%; P<0.05) with an odds ratio of 1.833 (CI95%= 1.126- 2.985). After adjustment of age, place of residence and BMI, Vitamin D levels were significantly associated with functional dyspepsia in the regression analysis.

Conclusion:

This study shows significant association of vitamin D deficiency in FD patients. It also opens up new avenues for further research into the role of vitamin D supplementation to further improve the management of such cases.

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