Association of Low-Density Lipoprotein Receptor-Related Protein-5 (LRP5) 4037C>T Polymorphism with Nephropathy in Patients with Type 1 Diabetes Mellitus
Hala Abdel Al, Rasha ElAdawy Shaaban, Doaa Mostafa Awad, Norhan Hossam El-deen Ibrahim- General Medicine
Abstract
Background
Type 1 diabetes mellitus (T1DM) is a heterogeneous and multifactorial endocrinal chronic disease. Genetic predisposition has a major impact on disease susceptibility. Microvascular complications such as diabetic nephropathy develops in T1DM in untreated cases.
Aim of the Study
the study investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) polymorphism 4037C>T and type 1 diabetes mellitus and the development of diabetic nephropathy.
Patients and Methods
This study included 40 T1DM pediatric patients and 20 age and sex matched healthy controls. All participants of the study were subjected to full history taking, clinical assessment, laboratory investigations and LRP5 gene (rs3736228) polymorphism assay by real time PCR.
Results
The present study showed no statistically significant difference between T1DM patients and their matched healthy subjects as regards LRP5 rs3736228 gene polymorphism. No statistically significant association was observed between LRP5 gene polymorphism and the development of diabetic nephropathy. Patients with CT genotype had a statistically significant association with obesity and hypercholesterolemia.
Conclusion
No association was found between LRP5 gene polymorphism rs3736228 and type 1 diabetes mellitus as well as the development of diabetic nephropathy among the studied pediatric population.