Association of gut microbiota with objective sleep measures in women with and without HIV infection: the IDOze study
Yanbo Zhang, Chin Lun Lin, Kathleen M Weber, Jiaqian Xing, Brandilyn A Peters, Christopher C Sollecito, Evan Grassi, Fanua Wiek, Xiaonan Xue, Eric C Seaberg, Deborah Gustafson, Kathryn Anastos, Anjali Sharma, Helen J Burgess, Robert D Burk, Qibin Qi, Audrey L French- Infectious Diseases
- Immunology and Allergy
Abstract
Background
Poor sleep health is an underrecognized health challenge, especially for people living with HIV. Gut microbiota related to sleep are under-investigated.
Methods
The IDOze microbiota substudy included 190 women (114 with HIV and 76 without HIV). Wrist actigraphy measured total sleep duration, sleep efficiency, number of wake bouts, wake after sleep onset, fragmentation index, and sleep timing. 16S rRNA gene sequencing identified gut microbial genera. Analysis of Compositions of Microbiomes with Bias Correction was used to investigate cross-sectional associations between gut microbiota and sleep. Abundances of sleep-related gut microbial genera were compared between women with and without HIV.
Results
Enrichment of seven short-chain-fatty-acid-producing genera (e.g., Butyricimonas, Roseburia, and Blautia) was associated with lower fragmentation index. Enrichment of nine genera (e.g., Dorea) was associated with lower sleep efficiency and/or more wake after sleep onset. Enrichment of proinflammatory Acidaminococcus was associated with late sleep midpoint and offset time. These associations were largely consistent regardless of HIV status. The abundance of Butyricimonas was lower among women with HIV compared to those without HIV.
Conclusions
Seventeen genera were identified to be associated with sleep continuity or timing. Butyricimonas, a potentially beneficial genus associated with sleep continuity, was less abundant among women with HIV.