Assessment of proxy‐reported responses as predictors of motor and sensory peripheral neuropathy in children with B‐lymphoblastic leukemia
Rozalyn L. Rodwin, Natalie J. DelRocco, Emily Hibbitts, Meenakshi Devidas, Moira K. Whitley, Caroline E. Mohrmann, Reuven J. Schore, Elizabeth Raetz, Naomi J. Winick, Stephen P. Hunger, Mignon L. Loh, Marilyn J. Hockenberry, Xiaomei Ma, Anne L. Angiolillo, Kirsten K. Ness, John A. Kairalla, Nina S. Kadan‐Lottick- Oncology
- Hematology
- Pediatrics, Perinatology and Child Health
Abstract
Chemotherapy‐induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy‐reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c‐index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism‐corrected models had weak discrimination (c‐index sensory models 0.65, 95% CI: 0.54–0.74). New proxy‐report measures are needed to identify children with PT/OT diagnosed CIPN.