Abstract 18378: Ischemic Heart Diseases Mortality is Decreasing in Older Women: A Population-Based Time-Trend Analysis Using the Global Burden of Diseases Database, 1990-2019

Introduction: Ischemic heart diseases (IHD) are a major cause of mortality in the US despite that there is limited data on recent age and sex-specific mortality rates.

Aim: This study aimed to conduct a time-trend analysis of mortality rates of IHD in the US using the global burden of disease (GBD) database.

Methods: Mortality data was obtained from the GBD database. Age-adjusted mortality rates were stratified by gender and age-specific groups: younger adults (≤55 years) and older adults (>55 years). Annual percentage change (APC) and average APC (AAPC) were estimated using Joinpoint Regression Software (v.4.9.0.1, NCI).

Results: 959,513 patients were diagnosed with IHD in the US in 2019. Overall, mortality rates have decreased in older adults but remained stable in younger adults (AAPC = -2.9 vs -1.0, AAPC difference = 1.9, P < 0.001). Similar trends were observed in men, with an AAPC difference between older and younger adult men (0.9, P < 0.001). In women, while similar results were seen, there was a greater AAPC difference between younger and older adult women (2.6, P < 0.001), suggesting that the disparity in IHD mortality rates between age-specific groups arises from women.

Conclusions: Our study showed decreasing IHD mortality rates among older adults and women over the past three decades. Further research is warranted to understand the factors behind the decreasing mortality rate in older adults, particularly older women.